The Molecular Basis of Cancer 4/e Expert Consult – Online and Print 2014

描述

The Molecular Basis of Cancer 4/e
Expert Consult – Online and Print

Author:Mendelsohn J.
Publisher:WB Saunders
ISBN:9781455740666
Pages:704
Product type:Book
Successfully fighting cancer starts with understanding how it begins. This thoroughly revised 3rd Edition explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of cancer. A team of leading experts thoroughly explain the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating cutting-edge advances and the newest research, the book provides thorough descriptions of everything from molecular abnormalities in common cancers to new approaches for cancer therapy. A new full-color format expedites reference, and a new bonus Expert Consult Edition website enables you to search the full text, download all of the book’s images for your personal use, and review periodic updates.

New to this edition

Features numerous descriptions of the latest clinical strategies—helping you to understand and take advantage of today’s state-of-the-art biotechnology advances.

By John Mendelsohn, MD, Professor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas ; Peter M. Howley, MD, Shattuck Professor of Pathological Anatomy, Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, Boston, Massachusetts ; Mark A. Israel, MD, Director, Norris Cotton Cancer Center, Professor of Pediatrics and Genetics, Dartmouth Medical School, Hanover, New Hampshire; Joe W. Gray, PhD, Gordon Moore Professor and Chair, Biomedical Engineering, Oregon Health and Science University (OHSU) Director, OHSU Center for Spatial Systems Biomedicine, Portland, Oregon; Emeritus Professor, UCSF, and Visiting Faculty, Lawrence Berkeley National Laboratory, Berkeley, California and Craig B. Thompson, MD, President and CEO, Memorial Sloan-Kettering Cancer Center, New York, New York

Table of Contents:

Part I: Carcinogenesis and Cancer Genetics

1. Cancer, A Genetic Disorder

2. Oncogenes and Signal Transduction

3. Tumor Suppressor Genes

4. Genomic Instability and DNA Repair

5. Epigenetics and Cancer

6. Infectious Agents and Cancer

7. Environmental Carcinogenesis

8. Animal Models: Flies, Fish and Yeast

9. Genetic Mouse Models of Cancer

Part II: Cancer Biology

10. Cancer Stem Cells

11. Regulation of the Cell Cycle

12. Cell Growth

13. Cancer Cell Metabolism

14. Apoptosis, Autophagy and Necrosis

15. Cell Growth Arrest and Senescence

16. Stromal-Cancer Interactions in the Microenvironment

17. Hypoxia and Angiogenesis

18. Invasion and Metastasis

19. Inflammation and Cancer

20. Molecular Pathways and Systems Biology

Part III: Molecular Pathology and Diagnostics

21. Biomarkers Assessing Risk of Cancer

22. Biomarkers for Detecting Cancer: Molecular Screening

23. Biomarkers for Predicting Response to Specific Therapy

24. The Technology of Analyzing Nucleic Acids

25. Imaging Cancer