Itch: Mechanisms and Treatment

描述

Itch: Mechanisms and Treatment (Frontiers in Neuroscience) 1st Edition
by E. Carstens (Editor), Tasuku Akiyama (Editor
Hardcover: 494 pages
Publisher: CRC Press; 1 edition (February 25, 2014)
Language: English
ISBN-10: 1466505435
ISBN-13: 978-1466505438
Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain.

Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer.

Composed of contributions from distinguished researchers around the world, the book explores topics such as:

Neuropathic itch

Peripheral neuronal mechanism of itch

The role of PAR-2 in neuroimmune communication and itch

Mrgprs as itch receptors

The role of interleukin-31 and oncostatin M in itch and neuroimmune communication

Spinal coding of itch and pain

Spinal microcircuits and the regulation of itch

Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.