Osteoporosis in Men, 2nd Edition The Effects of Gender on Skeletal Health

描述

Osteoporosis in Men, 2nd Edition
The Effects of Gender on Skeletal Health
Edited by Eric S. Orwoll, John P. Bilezikian and Dirk Vanderschueren

Copyright 2010

Key Features

Brings together more eminent investigators and clinicians to interpret developments in this growing field.

Describes state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy.

There is no book on the market that covers osteoporosis in men as comprehensively as this book.

Readership
Academic, medical, and pharmaceutical researchers in bone biology, endocrinology, and rheumatology; Medical researchers in pediatrics, internal medicine, orthopedics, primary care, geriatrics, obstetrics and gynecology, oncology, and nephrology.

Quotes

“The editors of Osteoporosis in Men, Second Edition have produced a comprehensive compendium about osteoporosis as it relates to men. An established group of experts has contributed to the second edition of this excellent book. The topics range from the basics of osteoporosis to sections on growth of the skeleton, aging, importance of nutrition, sex hormones, and the development of the disorder. Key sections of clinical relevance including diagnosis and treatment of osteoporosis in men are covered in depth. This book will serve as an excellent resource for established clinicians and investigators as well as for students and fellows.”

–Richard Eastell, MD, FRCP, FRCPath, FMedSci, Professor of Bone Metabolism, Director of the NIHR Bone Biomedical Research Unit, Centre for Biomedical Research, Northern General Hospital, Sheffield, South Yorkshire, United Kingdom

“The 10 sections and total of 57 informative chapters in the second edition of the text Osteoporosis in Men constitute an impressive body of up-to-date information by leading experts on this important topic. The text is particularly useful because of its breadth extending from basic bone biology and environmental factors affecting skeletal development in men to clinical chapters on pathophysiology, diagnosis, and therapy. The editors have provided a comprehensive yet practical approach to the topic which makes the text useful to a broad potential audience ranging from trainees to established leaders in the field.”

— John T. Potts, Jr., MD, Director of Research and Physician-in-Chief emeritus, Massachusetts General Hospital, Jackson Distinguished Professor of Clinical Medicine, Harvard Medical School, Boston, MA, USA

“This thorough and comprehensive book integrates new, accessible, and informative material in the field. It will help investigators, as well as practitioners and students, to improve their understanding of male skeletal health and male skeletal loss. The additional knowledge, assembled in such a readable manner, should help us achieve one of our ultimate goals, namely better care of men with osteoporosis.”

–Gerolamo Bianchi, MD, Department of Locomotor System, Division of Rheumatology, Azienda Sanitaria Genovese, Genova, Italy

Table of Contents

Section 1 – Essentials of bone biology

The Biochemistry of Bone: Composition and Organization

Adele L. Boskey

Bone Remodeling: Cellular Activities in Bone

David W. Dempster, Hua Zhou, Shi Shou Lu

Assessment of Bone Turnover Using Biochemical Markers

Patrick Garnero, Pawel Szulc

Fundamentals of Mineral Homeostasis

David A. Hanley, Shawn K. Davison

The Mechanical Properties of Bone

David P. Fyhrie

Assessment of Bone Architecture

Thomas F. Lang

Section 2 – Development and growth of the male skeleton

Skeletal Growth in Males

Qingju Wang, Ego Seeman

Pubertal Growth of the Male Skeleton

Vincent Gilsanz, Stefano Mora

The Effects of Sex Steroids on Bone Growth

Giampiero I. Baroncelli, Silvano Bertelloni

Nutritional Basis of Skeletal Growth

Connie M. Weaver, Elizabeth Haney

Physical Activity and Skeletal Growth

Heather M. Macdonald, Heather A. McKay, Melonie Burrows

Section 3 – Skeletal genetics

The Genetics of Peak Bone Mass

Luigi Gennari, Robert F. Klein, Serge Ferrari

Section 4 – Aging and the male skeleton

Age-Related Changes in Bone Remodeling and Micro Architecture

Roger Zebaze, Ego Seeman

Markers of Bone Remodeling and the Aging Skeleton

Serge Cremers, Christian Meier, Markus J. Seibel

Alterations in Mineral Metabolism in the Aging Male

Shonni J. Silverberg, Bismruta Misra

Change in Bone Size and Geometry with Aging

Pawel Szulc

Aging and Bone Density

Steven Boonen, Filip Callewaert, Katrien Venken, Dirk Vanderschueren

The Effect of Age on Material Properties

Charles H. Turner, Matt Allen, David Burr

Section 5, Nutritional issues

Calcium, Bone Strength and Fractures

Laura A.G. Armas, David P. Heaney, Joan M. Lappe

Vitamin D and Bone

Roger Bouillon, Christa Maes, Lieve Verlinden, Geert Carmeliet, Annemieke Verstuyf

Role of Dietary Protein in Bone Growth and Bone Loss

Rene Rizzoli

Section 6 – Sex steroids and the skeleton in men

The Molecular Biology of Sex Steroids in Bone: Similarities and Differences Among the Sexes

Stavroula Kousteni

Estrogen and the Skeleton – Rodents

Dirk Vanderschueren, Katrien Venken, Filip Callewaert, Steven Boonen

Estrogen and the Skeleton – Humans

Liesbeth Vandenput, Claes Ohlsson

Androgens and the Skeleton – Animal Models

Kristine Wiren, Eric Orwoll

Androgens and the Skeleton – Humans

Benjamin Z. Leder

Androgen Effects on the Skeletal Muscle

Shalender Bhasin, Rajan Singh, Ravi Jasuja, Thomas W. Storer

Section 7 – Fractures in men

Epidemiology of Fractures

Shreyasee Amin

Individualized Progress of Fractures in Men

Tuan V. Nguyen , John A. Eisman

Physical Activity, Physical Function and Fall and Fracture Risk in Older Men

Peggy Mannen Cawthon, Lynn Marshall

Economic Impact of Osteoporotic Fractures (vs women)

Terence O’Neill

Adverse Health Outcomes in Men with Osteoporosis

Deborah T. Gold, Stuart L. Silverman

Section 8. Metabolic bone disease in men

Idiopathic Osteoporosis

Jean-Marc Kaufman, Bruno Lepauw, Youri Taes, Stefan Goemeare

Glucocorticoid Induced Osteoporosis

Andrea Giustina, Gherardo Mazziotti

Testicular Dysfunction

David J. Handelsman, Christian Meier, Markus J. Seibel

Alcohol and Bone

Neil Binkley

Transplantation Osteoporosis

Elizabeth Shane, Juliet E. Compston, Emily Stein

Management of Fractures in Men with Impaired Renal Function

Paul D. Miller

Hyperparathyroidism

John P. Bilezikian, Claudio Marccoci

Hypercalciuria

Murray J. Favus

The Skeletal Phenotype of the Male Athlete

Clifford J. Rosen, Ann E. Maloney

Inherited and Related Disorders of Bone Matrix Synthesis in Men

Jay R. Shapiro

Section 9 – Diagnostic approach

Dual-Energy X-ray Absorptiometry (DXA) in Men

Neil C. Binkley, Robert A. Adler

Quantitative Ultrasound Diagnosis of Osteoporosis in Men

Robert A. Adler, Neil C. Binkley

Advanced Structural Assessment of Bone Using CT and MRI

X. Edward Guo, X. Sherry Liu, Felix W. Wehrli

Vertebral Fracture Assessments

Piet Geusens, Willem Lems

The Use of Bone Biopsies in the Diagnosis of Male Osteoporosis

Erik F. Eriksen, Johan Halse

Overall diagnostic strategy

Eric Orwoll

Section 10 – Therapy

Diagnostic Thresholds for Osteoporosis in Men

John A. Kanis, Anders Oden, Helena Johansson, Eugene V. McCloskey

Cost-Effectiveness of Interventions to Reduce Osteoporosis-Related Fractures in Men: Current Data, Controversies, and Challenges

John T. Schoesboe

Nutritional Therapy for Skeletal Health in Men

Deborah E. Sellmeyer, Diana M. Antoniucci

Exercise Programs for Patients with Osteoporosis

Dieter Felsenberg, Martin Runge

Calcitonin: History, Physiology, Pathophysiology and Therapeutic Applications

Sunil J. Wimalawansa

Treatment of Male Osteoporosis with Bisphosphonates

Socrates E. Papapoulos, Andrea Giusti

Treatment of Male Osteoporosis with Parathyroid Hormone

Monica Giotra, Felicia Cosman, John P. Bilezikian

Testosterone Therapy for Osteoporosis in Men

Kishore M. Lakshman, Andre B. Araujo, Shalendar Bhasin

57. Future Therapies: Strontium, SERMs, SARMs and New Therapies on the Horizon

Ghada El-Hajj Fuleihan, Mahmoud Tabbal